Stern, E., Fitzgerald, K., Welsh, R., Abelson, J., & Taylor, S. (2012). Resting-State Functional Connectivity between Fronto-Parietal and Default Mode Networks in Obsessive-Compulsive Disorder PLoS ONE, 7 (5)

zde:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0036356

OCD hyperaktivní DMN a málo napojeném na FCP, takže je to nevyhodí z vnitřních myšlenek k úkolům a vnější pozornosti:

 In healthy individuals, disengagement from internally-focused thought processes may rely on interactions between DMN and a fronto-parietal network (FPN) associated with external attention and task execution.

pak jsou OCD pořád ve své hlavě:

such as patients' inability to disengage from internally-generated scenarios and thoughts when performing everyday tasks requiring external attention


- zkoumá spojení FPC a DMN u OCD, když jsou v klidu

typická oblast mozku podporuje víc kognitivních funkcí, jedinečné funkcionální zapojení jde mezi oblastmi mozku:

 a typical brain area is likely to support multiple cognitive functions and that unique functionality is most likely to emerge through inter-regional connectivity


při výkonu, který potřebuje vnější pozornost, je lépe redukce DMN a aktivace FPC aktivizující DA:


 reductions in DMN activity[43], [44] and greater negative correlations between FPN and DMN [45] are associated with improved performance (and less “mind wandering") on tasks requiring externally-directed attention. FPN and DMN are also negatively correlated at rest, at least in healthy controls



možná DMN a DA sítě soupeří!:

the unconstrained brain may be intrinsically organized to support competitive relationships between networks involved in external attention and internally-focused thought processes.

zde by mohla ke slovu přijít Blacmoreová:

DMN je u OCD příliš mnoho okupováno memy, zejméne memplexem egoplexem - na úkor přežití a fitness organismu!!!

- rozdíly v zapojení v FPC, u OCD vyšší zapojení v klidu

- u klidových OCD nebyly rozdíly ve vnitřním zapojení DMN!!!

v klidu je vyšší spojení mezi FPC a DMN u OCD:

Primary results from the current study revealed reduced negative connectivity between the fronto-parietal network and default mode network in OCD.

- ale s menší signifikantostí mají OCD zapojenou DMN méně:

However, not all group differences reflected increased connectivity in OCD, as patients showed less positive connectivity than control subjects within DMN itself, although these effects only emerged at lower levels of significance. 

porušená kompetice DA a DMN:

 a disruption of the competitive interactions typically found at rest between fronto-parietal and default mode networks.

obvykle to šéfuje FPC:

 the relationship between fronto-parietal network regions involved in executive/control processes and DMN indicate that efficient processing of external stimuli requires the suspension of introspectively-oriented cognition [44], [45], and that this inverse pattern of activity appears even when the brain is at rest [18], [35], [46].